Growth Hormone · 10mg × 10 vials
In plain terms: CJC-1295 + Ipamorelin is a research compound - oral, long-acting and well studied.
CJC-1295 and ipamorelin work on two separate growth-hormone pathways that converge at the pituitary, which is why they are run together almost universally. CJC-1295 is a synthetic analog of growth-hormone-releasing hormone (GHRH 1-29) modified to resist enzymatic breakdown. It binds the GHRH receptor on pituitary somatotrophs and raises the baseline of how much GH the pituitary is ready to release on each pulse. Ipamorelin is a five-amino-acid GHRP that binds the ghrelin/GHS-R1a receptor and triggers the actual pulse of GH release. GHRH alone raises the amplitude of natural pulses; a GHRP alone triggers extra pulses but only as strong as baseline allows. Run together, the two receptors fire at the same time and the GH pulse is significantly larger than the sum of the parts (the Bowers synergy effect first published in 1991). The result is a stronger, more frequent, more physiological GH pulse than either compound alone, which downstream drives IGF-1 elevation in the liver and produces the recomp, recovery, sleep, and skin/collagen effects associated with elevated GH.
Two versions of CJC-1295 exist and they are NOT interchangeable. CJC-1295 no-DAC (often called "modified GRF 1-29") has a half-life of about 30 minutes and produces a sharp, short GH bump that mirrors natural pulse physiology, dose 1-3x daily. CJC-1295 with-DAC adds a Drug Affinity Complex (a maleimido-lysine that covalently binds endogenous serum albumin) that extends the half-life to 6-8 days and gives a constant elevated GH "bleed" rather than pulses, dose 1-2x weekly. The community is split on which is better and the choice drives the entire protocol - see Dose Tables. Ipamorelin's selling feature versus older GHRPs (GHRP-6, GHRP-2, hexarelin) is selectivity: in the original Raun 1998 swine study, ipamorelin released GH at potency equivalent to GHRP-6 but did NOT elevate ACTH, cortisol, or prolactin even at doses 200x above the GH ED50. That cleanness is why ipamorelin became the default GHRP for stacking - no cortisol spike means no anxiety/fat-storage signal, no prolactin spike means no nipple sensitivity or libido drop.
Typical dose ranges by experience level - educational reference. Message us and we tailor it to you.
Use the pre-blended CP10 kit (5 mg CJC no-DAC + 5 mg ipamorelin per vial, 10 vials per kit). At 250 mcg twice daily, one 10 mg vial lasts roughly 3-4 weeks; a kit covers 30-40 weeks of single-daily or 15-20 weeks of twice-daily use. Pre-bed dose is the high-leverage one. Beginners should NOT start with the with-DAC version - the constant GH elevation makes side effect timing harder to read.
3x daily dosing produces the cleanest results - three distinct GH pulses spread across the day matches natural physiology best. Pre-workout dose timed 30-45 min before training. This is the band where body composition changes (visible lean mass increase, slight fat loss at the waist, fuller-looking skin) become clearly visible by week 8-12.
The with-DAC vs no-DAC debate splits roughly 60/40 toward no-DAC in the peptide community. With-DAC pros: 2 shots a week is convenient, IGF-1 stays elevated 9-11 days from one dose. With-DAC cons: constant GH elevation is less physiological, more insulin resistance signal, harder to stop quickly if side effects emerge, longer washout. No-DAC pros: pulsatile, matches natural physiology, washes out within hours if there's a problem, cleaner side effect profile. No-DAC cons: 1-3 shots per day for 12 weeks is logistically heavier. Advanced users running with-DAC always pair it with daily ipamorelin to restore the pulse component.
Straight talk - what people actually report, and what the studies measured.
Peer-reviewed studies and clinical guidelines - tap any to read the source.
landmark CJC-1295 with-DAC pharmacokinetics, 5.8-8.1 day half-life, 2-10x GH elevation, 1.5-3x IGF-1 elevation
Read study ↗PubMedRaun K, Hansen BS et al, Ipamorelin, the first selective growth hormone secretagogue, Eur J Endocrinol 1998, 139(5):552-561:552-561](https://academic.oup.com/ejendo/article-abstract/139/5/552/6748390) - defining selectivity paper, ipamorelin releases GH at potencies similar to GHRP-6 without ACTH, cortisol, prolactin, FSH, LH, or TSH elevation even at 200x ED50
Read study ↗PubMedBowers CY, GHRH and GHRP synergy on GH releaseoriginal synergy demonstration showing co-administration produces GH response exceeding the sum of either alone (1991 framework, broadly cited)
Read study ↗PubMedSackmann-Sala L et al, A mechanistic view of growth hormone signaling pathwaysGHRH/GHRP receptor pathway separation framework
Read study ↗Clinical guidelinesCJC-1295 with-DAC complete research guide, Your Peptide Brand 2026synthesis of pharmacokinetics, RCT data, DAC mechanism
Read study ↗Clinical guidelinesCJC-1295 with-DAC vs without-DAC pharmacokinetic comparison, Particle PeptidesRead study ↗Aggregated sentiment from public forums & socials - real-world reports, not individual endorsements.
Hand tingling / morning numbness: most-reported "weird" sensation, peaks weeks 2-4, settles by week 6. Users describe it as a mild carpal-tunnel feeling, especially noticeable on waking. Drop dose 25-50% for one week if intrusive.
Water retention / "puffy" face or hands: common first 3-4 weeks, especially at 300 mcg dosing. Body adapts. Community fix: lower dose temporarily, increase water intake, reduce sodium.
Better sleep within 3-7 days: most-reported positive effect, often the first thing users notice - deeper sleep, more vivid dreams, harder to wake up. This is the "is it working" signal customers ask about most.
Increased hunger especially in the hour after pre-bed shot: mild for most, sharp for some. Drinking water before bed and not having food easily accessible solves it.
Slight fat loss around the waist + visible lean fullness: typical report by week 8-12, especially if training and protein intake are dialed in.
Skin quality, hair growth, faster recovery from workouts: common reports by week 4-6.
Route: SubQ (subcutaneous injection into abdomen or outer thigh fat)
Injection site: abdomen pinch (around the navel, 2 inches out) or outer thigh; rotate sites each shot, fresh insulin syringe each time
Storage: refrigerated, ~30 days after reconstitution. Unreconstituted vials stable at room temp short-term, refrigerate long-term. Don't freeze reconstituted vials.
Notes: Inject on an empty stomach - food (especially carbs/fat) blunts the GH pulse via insulin's suppressive effect on GH. Standard windows are first thing AM fasted, pre-workout fasted, and pre-bed at least 2 hours after last meal. Pre-bed dose is the highest-leverage shot because it stacks the induced GH pulse on top of the natural slow-wave-sleep pulse, which is why almost every protocol prioritizes the bedtime injection. CJC and ipamorelin are compatible in the same syringe (the kit is already pre-blended); no incompatibility issues with also drawing tesamorelin or GHK-Cu into the same pin per community reports, but separate pins are cleaner.