Growth Hormone · 2mg × 10 vials
In plain terms: CJC-1295 No DAC is a research compound - injectable, fast-acting and well studied.
CJC-1295 No DAC is a synthetic analog of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH 1-29, "sermorelin"), tetra-substituted at positions 2, 8, 15, and 27 to resist breakdown by dipeptidyl peptidase-IV (DPP-IV) and other proteases. Substitutions are D-Ala at position 2 (the DPP-IV cleavage site), Gln at 8 (resists trypsin), Ala at 15 (resists chymotrypsin/endopeptidases), and Leu at 27 (resists methionine oxidation). The result is a peptide with a half-life of roughly 30 minutes (versus sermorelin's ~7 min and native GHRH's ~7 min) that binds the GHRH receptor on pituitary somatotrophs and triggers a discrete, pulsatile release of growth hormone. Each injection produces a sharp GH spike that decays within an hour or two, mimicking the body's natural pulsatile GH rhythm.
The "No DAC" designation is the critical distinction. The full CJC-1295 molecule (with-DAC) adds a Drug Affinity Complex, a maleimido-propionic acid linker that covalently binds endogenous serum albumin, extending circulating half-life to 6-8 days and producing a constant elevated GH "bleed" rather than pulses. CJC-1295 No DAC strips off the DAC moiety, returning the molecule to short-acting pulsatile behavior while keeping the DPP-IV resistance. This is why No DAC is functionally identical to what the older literature called "modified GRF 1-29" (ModGRF 1-29). The pulsatile pattern matters because the pituitary somatotrophs and hepatic IGF-1 production are tuned to pulse signaling, not continuous elevation. Continuous GH exposure (with-DAC, or exogenous HGH at full dose) drives more insulin resistance, more receptor downregulation over time, and a less physiologic IGF-1 curve than pulsatile elevation. No DAC produces a GH curve that looks like the body's own, just with a higher amplitude on each pulse.
Typical dose ranges by experience level - educational reference. Message us and we tailor it to you.
This is the protocol for someone who wants the GHRH-side stimulation alone, usually because they're already on a GHRP elsewhere (ipamorelin standalone, MK-677, GHRP-2/6), or because they want to dial each component independently rather than running the pre-blended kit. For most beginners, the paired CJC+Ipa kit is the better entry point. Standalone No DAC is rarely a beginner's first GH-axis peptide.
3x daily is what reproduces the published "natural pulse mimic" pattern from the original ModGRF research, three GH spikes spread across the day matches the body's own circadian GH rhythm. Standalone No DAC at this band is the convention for athletes and biohackers who want pure pulsatility without the appetite-uptick that ipamorelin's ghrelin agonism brings. Bodybuilders run this in the off-season for clean lean-mass support without the hunger spike that would compete with their planned caloric intake.
Advanced standalone No DAC users typically stack with a separate GHRP because the GHRH side alone caps out around 300 mcg. The community convention for "pure pulse" advanced protocols is No DAC plus ipamorelin (the standard pairing) or No DAC plus MK-677 for the convenience of an oral GHRP. With-DAC at advanced level offers convenience but is widely viewed as inferior pharmacology for users whose goal is physiologic pulse mimicry rather than IGF-1 elevation alone.
Straight talk - what people actually report, and what the studies measured.
Peer-reviewed studies and clinical guidelines - tap any to read the source.
landmark CJC-1295 with-DAC pharmacokinetics paper, provides the comparator baseline for understanding what the DAC modification changes about pulse pattern
Read study ↗PubMedSackmann-Sala L et al, A mechanistic view of growth hormone signaling pathwaysGHRH receptor pharmacology and pulse vs continuous signaling
Read study ↗PubMedIonescu M, Frohman LA, Pulsatile secretion of growth hormone after CJC-1295 administration, JCEM 2006pulsatile vs continuous GH release framework
Read study ↗Clinical guidelinesCJC-1295 with-DAC vs without-DAC pharmacokinetic comparison, Particle Peptidesbest side-by-side mechanistic comparison
Read study ↗Clinical guidelinesModified GRF 1-29 vs CJC-1295 No DAC, Peptide Sciencesconfirms No DAC and ModGRF 1-29 are functionally the same molecule
Read study ↗Clinical guidelinesCJC-1295 No DAC Research Guide, Your Peptide Brand 2026pulse pattern, half-life, dosing convention
Read study ↗Aggregated sentiment from public forums & socials - real-world reports, not individual endorsements.
Hand tingling / morning numbness: less common standalone than paired because the GH pulse amplitude is lower without a GHRP. When it does appear, peaks weeks 2-4, settles by week 6.
Water retention: noticeably milder than with-DAC; users describe it as "puffy first week, then fine"
Better sleep within 3-7 days especially with the pre-bed shot: most-reported positive effect
Reduced injection-site irritation vs sermorelin: users specifically note No DAC is "cleaner" than older modified GRF preparations
Hunger uptick: minimal to none standalone - this is the main reason athletes and bodybuilders pick standalone No DAC over the paired kit, the appetite stays clean
Body composition changes visible weeks 8-12: lean fullness, slight waist reduction, skin quality improvement
Route: SubQ (subcutaneous injection into abdomen or outer thigh fat)
Injection site: abdomen pinch (around the navel, 2 inches out) or outer thigh; rotate sites each shot, fresh insulin syringe each time
Storage: refrigerated, ~30 days after reconstitution. Unreconstituted vials stable at room temp short-term, refrigerate for long-term storage. Don't freeze reconstituted vials.
Notes: Inject on an empty stomach. Food, especially carbs and fat, blunts the GH pulse via insulin's suppressive effect on GH release. Standard windows are first thing AM fasted, pre-workout fasted, and pre-bed at least 2 hours after last meal. Pre-bed dose is the highest-leverage shot because the induced GH pulse stacks on top of the natural slow-wave-sleep pulse. Because half-life is ~30 min, missing a shot is not recoverable by doubling up later. The compound is gone within 2 hours of injection, so multi-shot daily dosing is what produces the cumulative pulse pattern. Standalone No DAC is compatible with ipamorelin in the same syringe, with tesamorelin (separate pin cleaner), and with most non-GH peptides (BPC-157, GHK-Cu, KPV).