Nootropic · 5mg × 10 vials
it does not knock you out, it nudges the brain into the deep restorative phase of sleep that most poor sleepers spend too little time in.
DSIP (Delta Sleep-Inducing Peptide) is a 9-amino-acid neuropeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated in 1977 by the Schoenenberger and Monnier group at Basel from rabbit cerebral venous blood after low-frequency electrical stimulation of the intralaminar thalamic nuclei. It crosses the blood-brain barrier intact and shifts EEG architecture toward slow-wave (delta) activity, with the original characterisation studies showing roughly a 35% increase in delta activity in the neocortex and limbic cortex versus controls. It is not a sedative and does not bind GABA receptors directly; instead it modulates the sleep-wake system through stress-axis dampening (it attenuates stress-induced cortisol/corticosterone elevation), opioid-receptor adjacent activity (which is why it ameliorates opioid and alcohol withdrawal), and direct delta-wave promotion. In plain language: it does not knock you out, it nudges the brain into the deep restorative phase of sleep that most poor sleepers spend too little time in. Plasma half-life is short (~7-15 minutes by aminopeptidase/endopeptidase clearance), but the downstream effect on sleep architecture is long, with some users reporting better sleep for several nights after a single dose.
Typical dose ranges by experience level - educational reference. Message us and we tailor it to you.
Community lead Dr. William Seeds protocol is 100 mcg subQ ~3 hours before bedtime. Many first-timers don't feel anything for the first 3-4 doses, then suddenly notice better morning recovery. Pair with consistent bedtime and a dark room or the delta shift gets wasted.
Ben Greenfield runs 150 mcg, 3 nights per week to avoid tolerance. Jordan's house protocol for customer DMs is 200-400 mcg, 3-5x weekly, in 4-6 week cycles followed by an equal break. The break is the lever that keeps it working.
Top-end users almost always pair with Selank, oxytocin, or epithalon rather than push DSIP higher in isolation. The advanced move is stacking, not dose escalation.
Straight talk - what people actually report, and what the studies measured.
Peer-reviewed studies and clinical guidelines - tap any to read the source.
](https://pmc.ncbi.nlm.nih.gov/articles/PMC430668/) - original isolation, sequence determination, 35% delta increase
Read study ↗PubMedSchneider-Helmert & Schoenenberger 1981, Influence of synthetic DSIP on disturbed human sleephuman sleep architecture data in insomniacs
Read study ↗PubMedKovalzon & Strekalova 1987/2006, DSIP an updatereview of cortisol, LH, somatotropin modulation
Read study ↗PubMedDick et al, Successful treatment of withdrawal symptoms with DSIP (PMID 6328354)](https://pubmed.ncbi.nlm.nih.gov/6328354/) - 67-patient series, 97% opioid and 87% alcohol withdrawal symptom relief
Read study ↗PubMedDelta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke, Molecules 2021intranasal route, neuroprotective signal
Read study ↗PubMedPichia pastoris DSIP-CBBBP fusion peptide in PCPA-induced insomnia, 2024 (PMC11498945)](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11498945/) - modern BBB-penetrant DSIP research
Read study ↗Aggregated sentiment from public forums & socials - real-world reports, not individual endorsements.
"Felt nothing": the #1 community complaint. Either timing was wrong (too close to bedtime, too far before), dose was too low, or the product was degraded.
- Divergence: Clinical trials show statistically significant EEG delta increases; community is split 50/50 on subjective improvement. The objective measurement and the felt-effect don't always line up.
Paradoxical wired/arousal at 500 mcg+: reported often enough that community guides flag it as a real ceiling
Tolerance buildup with daily dosing: users running it every night report it stops working after 1-2 weeks (suspected delta-opioid receptor downregulation); the fix is to dose 3-5x per week, not daily
Mild temperature elevation: occasional report, transient
Vivid dreams: reported by a subset, sometimes positive ("more REM"), sometimes disruptive
Route: SubQ (primary). Intranasal route also studied and used by some prescribing peptide clinics, but the PP supply is injectable.
Injection site: abdomen or outer thigh, rotate sites. Subcutaneous, very small needle.
Storage: refrigerated 2-8 C, ~14 days after reconstitution per community consensus. Lyophilised vials store best at -20 C; refrigerator-only storage of the dry powder degrades potency.
Notes: Inject 1-3 hours before desired bedtime so the delta-shift effect lines up with sleep onset. Do not freeze the reconstituted vial. Use BAC water, not sterile water (sterile water has no preservative and contaminates fast). Inject the BAC down the side of the vial, do not jet it onto the powder cake or you foam the peptide and lose potency.