Metabolic Longevity · 10mg × 10 vials
In plain terms: Epithalon is a research compound - injectable, fast-acting and well studied.
Epithalon (Ala-Glu-Asp-Gly, also called Epitalon or AEDG) is a synthetic tetrapeptide modeled on Epithalamin, the polypeptide extract of the bovine pineal gland that Vladimir Khavinson's St. Petersburg Institute of Bioregulation and Gerontology spent decades studying starting in the 1970s. The headline mechanism is telomerase activation: in cultured human somatic cells, Epithalon induces transcription of the TERT gene (the catalytic subunit of telomerase), restores telomerase activity in cells that normally have it switched off, and extends telomere length by 33% in some passage studies, which lets fibroblasts complete additional Hayflick-limit divisions they otherwise would not. Beyond the telomere story, Epithalon acts as a bioregulator of the pineal axis: it restores age-related decline in pineal melatonin secretion, normalizes the diurnal cortisol rhythm, and modulates expression of clock genes (Per1, Per2, BMAL1, CLOCK) in peripheral tissues. Animal studies show it raises antioxidant defense (glutathione, SOD), reduces lipid peroxidation, and shifts the hypothalamic gonadotropin axis toward a younger pattern. In plain customer language: it is the "telomere/sleep peptide", it pulses the pineal gland back into a more youthful pattern, and the effects persist long after the 10-day course because gene expression and telomere length carry forward.
Typical dose ranges by experience level - educational reference. Message us and we tailor it to you.
This is the Khavinson "minimum effective protocol" and the most common community starting point. Most first-time users run two 10-day pulses per year (every 6 months). Sleep improvement is the most consistently reported subjective signal during the pulse, often noticeable by day 3-5. One ET10 kit (10 vials × 10 mg) covers one beginner pulse at 5 mg/day for 20 days, or two 10-day pulses if split tightly. The 10 mg vial size makes 5 mg dosing a half-vial proposition, so plan reconstitution accordingly.
10 mg/day for 10 days is the dose used in most published Khavinson cohort studies. Some intermediate users extend to 20 consecutive days once or twice per year (the original "geroprotector course"). One ET10 kit covers one 10-day pulse at 10 mg/day exactly. Customers serious about telomere/longevity work usually move to this dose after running one or two beginner pulses. The 5 mg/ml reconstitution gives a clean 2.0 ml dose per day (can be split into two 1.0 ml injections in different sites if 2 ml in one site is too much volume).
20-day continuous courses are documented in the older Russian protocols (Khavinson + Anisimov used 20-day intramuscular courses in elderly cohorts). The 10 mg BID protocol (~20 mg/day) is community-driven, not from Khavinson originals, and pulled from peptide forums where users wanted to compress a full course into 10 days. The ET50 kit (50 mg × 10 vials = 500 mg total) is the right buy at this level: one ET50 vial reconstituted to 5 ml at 10 mg/ml gives 5 daily doses of 10 mg from a single vial, so the full kit covers ~50 days of pulse work, enough for 2-5 advanced cycles. Advanced users almost universally pair Epithalon pulses with continuous HGH or CJC+Ipa work between pulses - the "stack the deck" anti-aging combo.
Straight talk - what people actually report, and what the studies measured.
Peer-reviewed studies and clinical guidelines - tap any to read the source.
foundational telomerase activation paper in human fibroblasts
Read study ↗PubMedKhavinson VK, Morozov VG - Peptides of pineal gland and thymus prolong human life, Neuro Endocrinol Lett 200312-year follow-up cohort, Epithalon + Thymalin combined, 1.6-1.8× mortality reduction in elderly
Read study ↗PubMedAnisimov VN, Khavinson VK - Peptide bioregulation of aging: results and prospects, Biogerontology 2010comprehensive review of the Khavinson peptide bioregulator program including Epithalon
Read study ↗PubMedKhavinson VK - Peptides and Ageing, Neuro Endocrinol Lett 2002, vol 23 suppl 3review of pineal peptide longevity work and the original Epithalamin → Epithalon synthesis story
Read study ↗PubMedKorkushko OV, Khavinson VK et al - Geroprotective effects of Epithalamin in elderly patients, Bull Exp Biol Med 2007clinical cohort showing restored melatonin secretion and circadian rhythm normalization
Read study ↗PubMedAnisimov VN, Khavinson VK et al - Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice, Mech Ageing Dev 2003animal lifespan extension data, addresses the tumor question (no increased tumor incidence at protocol doses)
Read study ↗Aggregated sentiment from public forums & socials - real-world reports, not individual endorsements.
Vivid dreams: most-reported subjective effect, often noticed by day 2-3 of the pulse. Users describe more cinematic, narrative-rich dreams. Tied to the pineal/melatonin reset.
Improved sleep depth and morning energy: very consistent across r/Peptides, peptide forums, and longevity Twitter. Many users report falling asleep faster and waking more refreshed during the 10-day pulse, with the effect persisting weeks-to-months after.
Mild euphoria or mood lift: reported by a subset of users, attributed to the serotonin/melatonin pathway influence
Reduced anxiety / calmer baseline: secondary signal, less universal than the sleep effect
Headache: occasional, usually mild and self-limiting in the first 1-3 days of a pulse, attributed to melatonin pathway shift
Skin/hair quality improvements: anecdotal, slower-build signal across multi-pulse users (1-2 years of biannual pulsing)
Route: SubQ injection (most common in research and community use). Intranasal and IM are documented in some Khavinson protocols; subQ is the PP default.
Injection site: abdomen or outer thigh, rotate sites
Storage: refrigerated, ~28 days. Lyophilized vials store room temp short-term, refrigerate or freeze for longer-term hold. Light sensitivity is low compared to BPC/TB but standard practice is amber-glass or fridge storage out of direct light.
Notes: Evening injection is preferred since the pineal/melatonin axis is the primary target. Most users dose 30-60 min before bed so the peptide is in circulation during the natural melatonin onset window. The peptide is cleared quickly so timing matters more than for long-half-life compounds like reta. Don't shake the vial; swirl gently to dissolve.