Growth Hormone · 5mg × 10 vials
In plain terms: GHRP-6 is a research compound - oral, fast-acting and well studied.
GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) is a synthetic six-amino-acid peptide developed by Cyril Bowers and Frank Momany in the early 1980s, the original "growth hormone releasing peptide" that defined the class. It binds the growth hormone secretagogue receptor (GHS-R1a) on pituitary somatotrophs and on hypothalamic neurons that drive feeding behavior, triggering a pulse of growth hormone release and a sharp central appetite signal. The same receptor was later identified (in 1999) as the endogenous target of ghrelin, the gut-derived "hunger hormone", which is why GHRP-6 is best understood as a ghrelin mimetic: it tells the body it's hungry and it tells the pituitary to fire a GH pulse, simultaneously.
What separates GHRP-6 from the cleaner modern GHRPs (ipamorelin, the gold standard, and to a lesser extent GHRP-2) is the breadth of receptor activity. At doses that release GH, GHRP-6 also meaningfully elevates ACTH, cortisol, and prolactin via downstream HPA activation, and the appetite signal is so strong it's the defining clinical effect. Ipamorelin, developed in 1998 specifically to fix this, releases GH at similar potency without the cortisol/prolactin spike and without the dramatic hunger bump. That selectivity gap is the reason GHRP-6 was largely replaced by ipamorelin in modern stacks. GHRP-6 still has a defined niche where its weaknesses are features: bulking phases where the appetite spike helps drive a caloric surplus, and wasting/cachexia contexts (cancer cachexia, HIV wasting, post-surgical anorexia) where stimulating food intake is the primary clinical goal.
Typical dose ranges by experience level - educational reference. Message us and we tailor it to you.
100 mcg is the saturating dose for the GH pulse at the GHS-R1a receptor. Doses above 100 mcg per injection do not produce additional GH release; they only amplify the off-target signals (cortisol, prolactin, hunger). This is the single most important dosing principle for GHRP-6 and the one most new users get wrong. Beginners should resist the urge to chase 200-300 mcg per shot; instead, add a third daily injection to get more pulses across the day. Pre-bed shot is the highest-leverage one because it stacks with natural slow-wave-sleep GH; AM fasted is second.
Three daily pulses mirror natural GH physiology better than two larger pulses. The appetite spike compounds across the day, this is the entire point in a bulking protocol. Cortisol and prolactin elevation is real at this band, monitor for anxiety, water retention, nipple sensitivity, libido changes. Stack with CJC-1295 (no DAC, 100 mcg same shot) for the Bowers synergy and to amplify the GH pulse beyond what GHRP-6 alone delivers.
Advanced GHRP-6 users almost always pair with CJC-1295 (no DAC) and frequently with AAS during a bulking cycle, using the appetite stimulation to drive the caloric surplus a heavy lifter needs. The modern advanced user has mostly migrated to CJC+Ipa or HGH for cleaner pulses; GHRP-6 advanced protocols are now niche, kept alive by old-school bodybuilders, wasting/cachexia research contexts, and customers who specifically want the appetite stimulant feature.
Straight talk - what people actually report, and what the studies measured.
Peer-reviewed studies and clinical guidelines - tap any to read the source.
:1537-1545, PMID 6714155](https://pubmed.ncbi.nlm.nih.gov/6714155/) - the foundational synthesis paper, Bowers/Momany's original characterization of the GHRP-6 hexapeptide
Read study ↗PubMedSmith RG, Van der Ploeg LH, Howard AD et al. Peptidomimetic regulation of growth hormone secretion. Endocr Rev 1997, 18(5):621-645:621-645](https://pubmed.ncbi.nlm.nih.gov/9331545/) - review of the GHRP class through 1997, before ghrelin was identified, contextualizes GHRP-6's positioning
Read study ↗PubMedKojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402(6762):656-660:656-660](https://pubmed.ncbi.nlm.nih.gov/10604470/) - the discovery paper for ghrelin as the endogenous GHS-R1a ligand, retroactively explains GHRP-6's appetite signal
Read study ↗PubMedRaun K, Hansen BS, Johansen NL et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol 1998, 139(5):552-561, PMID 9849822:552-561, PMID 9849822](https://academic.oup.com/ejendo/article-abstract/139/5/552/6748390) - the ipamorelin paper that directly compared selectivity against GHRP-6 in pigs, established the cortisol/prolactin gap that drove ipamorelin to become the default GHRP
Read study ↗PubMedLocatelli V, Torsello A. Growth hormone secretagogues: physiological role and clinical utility. Endocrine 2014, 47(3):788-803:788-803](https://pubmed.ncbi.nlm.nih.gov/24846777/) - review covering clinical positioning of GHRP-6 in cachexia, wasting, and frailty contexts
Read study ↗PubMedNass R et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults. Ann Intern Med 2008, 149(9):601-611:601-611](https://pubmed.ncbi.nlm.nih.gov/18981485/) - MK-677 / ibutamoren data, the comparator for chronic GHS-R1a agonism vs the GHRP-6 acute-pulse approach
Read study ↗Aggregated sentiment from public forums & socials - real-world reports, not individual endorsements.
"Hunger like nothing else": single most-reported effect across r/Peptides, bodybuilding forums, and old-school community archives. Users describe it as "ghrelin on tap", sharper and more sustained than ipamorelin's hunger bump, in the same class as or exceeding MK-677 for raw appetite stimulation. Onset within 15-30 min, peaks 30-45 min, lasts 60-90 min.
Cortisol-driven feelings: anxiety bump, mild jitteriness, water retention, sleep disruption if dosed too late in the day. More noticeable in lean users (lower baseline cortisol tolerance) and in users who don't pair with a GHRH analog (the synergy paradoxically softens some of the cortisol signal by raising GH amplitude faster).
Sleep effects: pre-bed dose deepens sleep when cortisol signal is controlled, but for cortisol-sensitive users the pre-bed shot causes early waking or shallow sleep. This is a known split in the community, run it for a week and find out which camp you're in.
Lean fullness / pump quality: reported by week 4-6, similar to other GHRPs.
Mild nipple sensitivity: low-incidence community report, prolactin-driven, more common in advanced-dose users and in users with elevated baseline prolactin.
Energy / drive bump on pre-workout shot: commonly reported, partly attributable to the cortisol/ACTH signal which has subjective overlap with stimulant feel.
Route: SubQ (subcutaneous, abdominal fat or outer thigh)
Injection site: abdomen pinch (2 inches lateral to navel) or outer thigh, rotate sites each shot. Insulin syringe fresh per draw.
Storage: refrigerated, ~30 days after reconstitution. Unreconstituted vials stable at room temperature short-term, refrigerate for long-term storage. Do not freeze reconstituted vials. Allow refrigerated vials to reach room temperature for a couple of minutes before injecting.
Notes: Inject fasted, 30+ minutes before food. The GH pulse is blunted by carbohydrate or fat in the system because insulin and free fatty acids suppress pituitary GH release. Standard timing windows are first thing AM fasted, pre-workout 30-45 min before training, and pre-bed at least 2-3 hours after the last meal. The appetite spike kicks in within 15-30 minutes of injection and lasts 60-90 minutes, peak around 30-45 min. This is the headline subjective effect, the GH pulse is what you're paying for but the hunger is what you feel.