Other · 5000iu × 10 vials
In plain terms: HCG (Human Chorionic Gonadotropin) is a research compound - injectable, fast-acting and well studied.
HCG is a glycoprotein hormone (~244 amino acids, alpha + beta subunit dimer) naturally produced by the placenta during pregnancy. Its alpha subunit is identical to LH, FSH, and TSH; its beta subunit is ~85% homologous to LH, which is why it binds and activates the LH/CG receptor on testicular Leydig cells with high affinity. In men this directly stimulates intratesticular testosterone production and downstream spermatogenesis support, completely bypassing the hypothalamus and pituitary (it does not require GnRH or LH from the brain). On exogenous testosterone, the brain shuts down its own LH signal and the testes atrophy and stop producing intratesticular T; HCG keeps the Leydig cells firing through that suppression, preserving testicular volume, intratesticular T (which is roughly 100× serum T and required for sperm production), and the ability to recover natural function after the cycle ends. In women HCG triggers ovulation by mimicking the mid-cycle LH surge, which is its FDA-approved use. The mechanism is purely receptor-level mimicry of LH at the gonad. The hormone has zero direct effect on adipocytes, appetite, or fat metabolism, which is the molecular reason the Simeons "HCG diet" cannot work as advertised.
Typical dose ranges by experience level - educational reference. Message us and we tailor it to you.
This is the TRT companion protocol used by virtually every well-run men's health clinic in the US. Goal is testicular volume preservation, intratesticular T maintenance, and keeping the option of fertility open. At this dose range estrogen aromatization is minimal in most users; only push higher if testicular atrophy is already significant.
Running HCG throughout the AAS cycle (not just at the end) is what most modern coaches recommend over the older "HCG only during PCT" school. Keeping the Leydig cells active during suppression means PCT recovery is faster and more reliable. Estrogen can creep up at 1000+ IU/wk, so AI dosing may need a small bump.
Straight talk - what people actually report, and what the studies measured.
Peer-reviewed studies and clinical guidelines - tap any to read the source.
landmark TRT + HCG sperm preservation study
Read study ↗PubMedKim ED et al, Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, BJU International 2013enclomiphene context for HCG alternative
Read study ↗PubMedCoviello AD et al, Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression, JCEM 2005the foundational paper showing 250 IU EOD HCG maintains ~26% intratesticular T, 500 IU EOD ~57%, 125 IU EOD insufficient
Read study ↗PubMedLiu PY et al, Rate, extent, and modifiers of spermatogenic recovery after hormonal male contraception, Lancet 2006fertility recovery rates after androgen suppression
Read study ↗PubMedLijesen GK et al, The effect of human chorionic gonadotropin (HCG) in the treatment of obesity by means of the Simeons therapy: a criteria-based meta-analysis, Br J Clin Pharmacol 1995in the treatment of obesity by means of the Simeons therapy: a criteria-based meta-analysis, Br J Clin Pharmacol 1995](https://pubmed.ncbi.nlm.nih.gov/8527285/) - the meta-analysis that conclusively debunks the HCG diet
Read study ↗PubMedBosch B et al, Effects of human chorionic gonadotropin on weight loss, hunger, and feeling of well-being, Am J Clin Nutr 1990second confirmatory debunk paper
Read study ↗Aggregated sentiment from public forums & socials - real-world reports, not individual endorsements.
Gyno / sensitive nipples: most-reported issue, almost always at 1000+ IU/wk total dose; manageable by lowering dose or adding AI
Testicular ache: very common in first 2 weeks as testes come back online from atrophy; usually resolves
Increased libido / morning wood: reported as positive side effect on TRT, often the first noticeable change at 1-2 weeks
Acne flare: especially in users prone to it; comes from intratesticular T → DHT spike
Water retention / facial bloat: at higher doses, manageable with sodium control
Mood lift or mood swing: split reports, some users feel better, others get irritable particularly at higher doses
Route: SubQ or IM (both clinically validated, subQ has become the community default for TRT companion dosing because it's less painful and absorption is functionally equivalent for the small TRT-range doses)
Injection site: SubQ abdomen or outer thigh (rotate). IM glute or quad for traditional protocols.
Storage: Refrigerated, 30-60 days. HCG is fragile post-reconstitution; do not freeze, do not shake (swirl), keep cold continuously. Lyophilized (unmixed) vial is stable at room temp for weeks but should be refrigerated long-term.
Notes: Use bacteriostatic water (BAC) not sterile water for multi-dose vials. Allow the vial to come to room temp before drawing once mixed. Don't pre-fill syringes more than a day in advance, the peptide degrades. Some users report reduced potency past ~30 days even refrigerated, so 5000 IU vials are often the more practical kit size for TRT companion dosing (one vial = ~5 weeks of 500 IU 2x/wk before degradation matters).