Growth Hormone · 5mg × 10 vials
In plain terms: Hexarelin is a research compound - injectable, fast-acting and well studied.
Hexarelin is a synthetic hexapeptide (His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2) and the most potent agonist in the GHRP (growth hormone releasing peptide) family. It binds the ghrelin receptor (GHSR-1a) in the hypothalamus and pituitary somatotrophs, triggering a sharp pulse of endogenous growth hormone. Structural modifications (D-2-methyl-tryptophan at position 2, D-phenylalanine at position 6) lock the molecule into a high-affinity conformation, giving it roughly 30x the GHSR-1a binding affinity of GHRP-6 and producing the largest GH spike of any peptide in the GHRP class. It is superior to GHRH alone and to GHRP-6 in stimulating GH release, and combines with a GHRH analog (CJC-1295, sermorelin, mod-GRF) for synergistic GH output that exceeds the sum of either alone (the Bowers synergy effect documented since 1991).
Hexarelin has a second mechanism that the cleaner GHRPs (ipamorelin) do not: it binds the CD36 scavenger receptor on cardiomyocytes, activating PI3K/Akt signaling, upregulating heat shock proteins (HSP-70, HSP-90) and anti-apoptotic Bcl-2, and reducing mitochondrial cytochrome c release. This is independent of GH and persists in GH-deficient animals. In rat heart failure models, chronic hexarelin (100 mcg/kg twice daily, 4 weeks) improved cardiac output 28%, reduced left ventricular end-diastolic pressure 34%, and cut cardiac fibrosis markers 40-45%. The CD36 angle is why hexarelin keeps showing up in cardio-research stacks even though it is not the cleanest option for pure GH work. The tradeoff: hexarelin pulls cortisol, prolactin, and ACTH up alongside GH (similar to GHRP-6, dramatically more than ipamorelin), and the GHSR-1a receptor desensitizes within 10-14 days of continuous dosing, capping useful cycle length.
Typical dose ranges by experience level - educational reference. Message us and we tailor it to you.
This is the recommended entry tier and what almost every first-time GHRP user should run. The single biggest beginner mistake is dosing too soon after a meal (kills the pulse) or stacking it with food. Empty stomach, wait 20-30 min before eating after injection. Head rush / tingling / hunger spike in the first 5 minutes post-injection is normal and indicates ghrelin receptor activation. If cortisol-feeling sides (anxiety, sweating, racing pulse) are pronounced, hexarelin is the wrong GHRP for that user, switch to ipamorelin.
This is the working dose band for recovery, sleep depth, and IGF-1 lift. Pair with CJC-1295 (no-DAC / mod-GRF 1-29) at the same dose timing for the Bowers synergy effect, GH output is 2-3x what hexarelin alone delivers. Mod-GRF + hex is the more researched combo than DAC-version; DAC keeps GHRH elevated continuously which blunts the pulsatile pattern hexarelin is good for. Watch for fluid retention and mild paresthesia (tingling in hands/feet) at this dose, usually settles by week 2.
This is the cardio-research / max-GH-pulse tier. Above 200 mcg per dose is wasted, the receptor saturates. Cumulative receptor desensitization is the hard ceiling, GH response measurably blunts at week 2 of continuous dosing and is significantly attenuated by week 4. Some advanced users rotate between hex and ipamorelin during the off block to keep some GHSR-1a activity going without compounding hex-specific desensitization. Cycling discipline matters more here than at any other tier, ignoring the off-block makes the next on-cycle useless.
Straight talk - what people actually report, and what the studies measured.
Peer-reviewed studies and clinical guidelines - tap any to read the source.
](https://pubmed.ncbi.nlm.nih.gov/9801989/) - age-stratified GH response, basis for elderly caution flag
Read study ↗PubMedHexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers (PMID 15177700)](https://pubmed.ncbi.nlm.nih.gov/15177700/) - cortisol/prolactin/ACTH elevation signal alongside GH
Read study ↗PubMedEffects of GHRP-2 and hexarelin, two synthetic GH-releasing peptides, on GH, prolactin, ACTH and cortisol levels in man (PMID 9285939)](https://pubmed.ncbi.nlm.nih.gov/9285939/) - direct hormonal profile vs GHRP-2
Read study ↗PubMedMechanism of action of hexarelin and GHRP-6: analysis of the involvement of GHRH and somatostatin in the rat (PMID 7731497)](https://pubmed.ncbi.nlm.nih.gov/7731497/) - GHSR-1a + GHRH synergy basis
Read study ↗PubMedCD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart (PMID 11988484)](https://pubmed.ncbi.nlm.nih.gov/11988484/) - CD36 cardioprotective mechanism, basis for cardio-stack positioning
Read study ↗PubMed / PMCThe cardiovascular action of hexarelin (PMC4178518)](https://pmc.ncbi.nlm.nih.gov/articles/PMC4178518/) - full cardiovascular review
Read study ↗Aggregated sentiment from public forums & socials - real-world reports, not individual endorsements.
Head rush / flush at injection: described as warm wave or tingling within 1-3 minutes of subQ injection, normal indicator of GHSR-1a hit
Hunger spike: dramatic, ghrelin-receptor activation, users report having to schedule meals around it or pair with appetite-suppressing compounds
Deeper sleep / vivid dreams: reported by most users within 1-2 weeks, the most positive subjective effect
Faster recovery / nail and hair growth: noted around week 2-3
Sweating, anxiety-flavored pulse spike: cortisol signature, more pronounced in cortisol-sensitive users
Diminishing returns by week 3-4: clear consensus across forums that hex stops feeling effective around 3-4 weeks even at the same dose, hard cutoff for cycling
Route: SubQ (IM also valid, no clinical difference in GH response for this class)
Injection site: abdomen subQ, rotate sites; can also do thigh or deltoid
Storage: refrigerated, ~28 days after reconstitution; unreconstituted vials stable at room temp short-term, refrigerate for long-term
Notes: Dose on an empty stomach (carbs and fats blunt the GH pulse for 1-2 hours post-injection). Best windows: first thing AM (pre-breakfast), pre-workout, and pre-bed. Allow 4+ hours between doses (8-12 hr preferred) for partial GHSR-1a recovery. Reconstitute with bacteriostatic water, swirl gently, do not shake. Light-sensitive, keep vial in box.