Sexual Health · 5mg × 10 vials
In plain terms: Kisspeptin-10 is a research compound - oral, fast-acting and well studied.
Kisspeptin-10 is a decapeptide (the shortest active fragment of the KISS1 gene product, residues 112-121 of the parent kisspeptin-54) that sits at the very top of the reproductive hormone cascade. It binds the KISS1R receptor (also called GPR54), a G-protein coupled receptor on GnRH neurons in the hypothalamus. When KISS1R fires, the GnRH neurons release gonadotropin-releasing hormone in pulses, which then drives the pituitary to release LH and FSH, which then drive the testes (testosterone, sperm) or ovaries (estrogen, ovulation). In other words, kisspeptin is the upstream switch for the entire HPG axis. Loss-of-function mutations in KISS1 or GPR54 cause complete failure of puberty without affecting any other pituitary function, which is how Seminara and Crowley's group at MGH originally established it as the GnRH pulse generator. Beyond the hormonal cascade, kisspeptin receptors are also expressed in limbic structures (amygdala, hippocampus, cingulate, putamen), which is why Comninos and Dhillo's work at Imperial College shows kisspeptin enhances neural activity in sexual-arousal and attraction circuits, even independent of the hormonal rise. So one peptide does two related but distinct things: it kicks the testes/ovaries on through the GnRH cascade, and it lights up the brain regions that drive sexual desire and emotional bonding.
Typical dose ranges by experience level - educational reference. Message us and we tailor it to you.
100 mcg is the floor community dose and matches the lower end of the published research range (clinical IV bolus at 0.24 nmol/kg works out to roughly 100 mcg in an 80 kg adult). Most users do not feel anything dramatic at this dose other than mild warmth and a libido lift over the next hour or two. Pair with PT-141 for first-time users wanting a noticeable arousal effect, since PT-141 is the louder of the two.
This is the band where bodyweight-corrected dose lines up with the published kisspeptin-10 LH-surge studies. Excelmale forum users running 150-200 mcg M-W-F alongside TRT report meaningful libido and mood lift; one user reported a 40% total testosterone bump after 1 month at 100 mcg daily (but stacked with tesa/CJC/ipa so attribution is muddy). For HSDD-type use cases in men, this is the working dose.
500 mcg is roughly the ceiling for the published kisspeptin-10 IV bolus dose where LH response is maximal; above this the receptor starts showing signs of desensitization (the original Seminara group saw a paradoxical drop in LH at 3 mcg/kg vs 1 mcg/kg, suggesting GPR54 downregulation at very high acute doses). Advanced fertility protocols and post-AAS HPG restart work in this band, often paired with HCG. Sexual-application users rarely need to push this high.
Straight talk - what people actually report, and what the studies measured.
Peer-reviewed studies and clinical guidelines - tap any to read the source.
](https://pmc.ncbi.nlm.nih.gov/articles/PMC3380939/) - IV bolus dose-response, LH surge at 1 mcg/kg, pulse-frequency increase, zero AEs
Read study ↗PubMedComninos et al, JCI 2017, Kisspeptin modulates sexual and emotional brain processing in humans (PMC5272173)](https://pmc.ncbi.nlm.nih.gov/articles/PMC5272173/) - fMRI limbic activation, amygdala/caudate/putamen/thalamus enhancement to sexual stimuli
Read study ↗PubMedMills, Comninos, Dhillo et al, JAMA Network Open 2023, Kisspeptin in HSDD men (PMC9898824)](https://pmc.ncbi.nlm.nih.gov/articles/PMC9898824/) - randomized crossover trial, +56% penile tumescence vs placebo, brain-network modulation, well tolerated
Read study ↗PubMedJayasena et al, Hypothalamic Amenorrhea + Kisspeptin-54 infusion (PMC4207927)](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207927/) - LH pulsatility restoration in women
Read study ↗PubMedPatel et al, Annals NY Acad Sci 2024, Kisspeptin in functional hypothalamic amenorrheacurrent state of the therapeutic landscape
Read study ↗PubMedHypothalamic-Pituitary-Ovarian Axis Reactivation by Kisspeptin-10 in Hyperprolactinemic Women with Chronic Amenorrhea (PMC5686678)](https://pmc.ncbi.nlm.nih.gov/articles/PMC5686678/) - Kp-10 restoring cycles in hyperprolactinemic patients
Read study ↗Aggregated sentiment from public forums & socials - real-world reports, not individual endorsements.
Mild facial flushing / warmth in first 20-30 minutes after injection - most-reported sensation
Slight headache at higher doses (300+ mcg), usually resolves within an hour
Libido/arousal lift in the 1-3 hour window post-injection - primary reason most PP customers run it
Mood lift / emotional connectivity - Comninos's limbic activation translates anecdotally as "feeling more attached/affectionate", reported by users running it in couples-focused stacks with oxytocin
Injection site soreness rare since dose volumes are tiny (4-20 IU on a U-100)
No reported negative impact on natural testosterone production when used as-needed; the concern would be receptor desensitization from chronic high-dose use, which the community has not seen at 100-500 mcg per dose ranges
Route: SubQ (clinical trials used IV bolus; community/PP customers use SubQ, which gives a slightly slower but still rapid LH response)
Injection site: abdomen subQ, rotate sites
Storage: refrigerated, ~28 days. Freeze the spare vials, lyophilized powder is good 12+ months frozen.
Notes: Half-life is short (~28 min for kisspeptin-10 vs ~4 hr for kisspeptin-54), so effect window is real but brief. For sexual application, dose 60-90 min before activity. For fertility/HPG protocols, multiple doses per week are standard because the LH bump from any single shot does not persist past a few hours.