Metabolic · 10mg × 10 vials
Lipolytic injection blend studied for localized adipocyte breakdown.
Lemon Bottle is a Korean-origin injectable lipolysis cocktail marketed for localised fat reduction. Unlike Aqualyx and Kybella, which use deoxycholic acid as a detergent to lyse adipocyte membranes, Lemon Bottle is a multi-ingredient cosmetic blend: riboflavin (vitamin B2, the source of its yellow colour), bromelain (a pineapple-derived proteolytic enzyme), lecithin (phosphatidylcholine, a surfactant emulsifier), and L-carnitine (a mitochondrial fatty-acid shuttle).
The proposed mechanism is that lecithin disrupts adipocyte membranes and emulsifies released triglycerides, bromelain assists in clearing tissue debris and reducing oedema, L-carnitine shuttles freed fatty acids into mitochondria for oxidation, and riboflavin serves as a coenzyme cofactor for fat metabolism. Important caveats apply: there are no published randomised controlled trials of the formulation, no peer-reviewed efficacy studies, the regulatory status outside Korea is unsettled (the UK MHRA has issued warnings and the US FDA has approved no lipolytic other than deoxycholic acid), and the mechanistic claims are extrapolated from the individual ingredients rather than measured for the finished product. Deoxycholic acid remains the only injectable lipolytic with a clinical evidence base.
What the published studies measured.
Peer-reviewed studies and clinical guidelines - tap any to read the source.
public health warning, unauthorized for UK sale, seized batches with unverified contents
Read study ↗PubMedRotunda AM, Suzuki H, et al, Detergent effects of sodium deoxycholate as the mechanism of action for KYBELLA/REFINE trialsclass mechanism for injection lipolysis, useful as the deoxycholic acid comparator Lemon Bottle is marketed against
Read study ↗PubMedJones DH et al, ATX-101 (deoxycholic acid) Phase 3 REFINE-1 and REFINE-2 trial outcomes, JAAD 2016Phase 3 REFINE-1 and REFINE-2 trial outcomes, JAAD 2016](https://pubmed.ncbi.nlm.nih.gov/26830864/) - submental fat reduction efficacy and AE rates for the validated lipolysis category
Read study ↗PubMedSchuller-Petrović S et al, Injection lipolysis with phosphatidylcholine/deoxycholate, J Cosmet Dermatol 2008phosphatidylcholine class injection lipolysis (lecithin is a phosphatidylcholine, so this is the closest peer-reviewed substrate for one of Lemon Bottle's ingredients)
Read study ↗PubMedBromelain anti-inflammatory and proteolytic activity, Biotechnol Res Int 2012 (PMC3529416)](https://pmc.ncbi.nlm.nih.gov/articles/PMC3529416/) - mechanism reference for bromelain's role in the blend
Read study ↗Clinical contextAmerican Society for Dermatologic Surgery, injection lipolysis position statementclass-level positioning for cosmetic lipolysis
Read study ↗Storage: refrigerated 2-8°C, opened vial typically discarded after a single session (no preservative system documented for multi-session use of the same vial)