Metabolic Longevity · 100mg × 10 vials
In plain terms: NAD+ is a research compound - injectable, long-acting and well studied.
NAD+ (nicotinamide adenine dinucleotide) is not a peptide - it is a coenzyme present in every cell in the body, and it is the central electron carrier of cellular metabolism. Every step of converting food into ATP (the Krebs cycle, oxidative phosphorylation) requires NAD+ as a substrate, and it is also the obligate substrate for two major enzyme families implicated in aging: the sirtuins (SIRT1-7, which regulate DNA repair, mitochondrial biogenesis, and stress response - they cannot function without NAD+) and the PARPs (poly-ADP-ribose polymerases, which repair DNA double-strand breaks and consume large amounts of NAD+ doing so). Tissue NAD+ levels decline 50%+ between age 20 and 60, which is why aging is associated with mitochondrial dysfunction, slower DNA repair, and reduced sirtuin activity. Supplementing NAD+ - either directly (IV, IM, subQ) or via precursors (NMN, NR, niacin) - raises intracellular NAD+ pools and reactivates these pathways.
The mechanistic debate that matters for customers: Charles Brenner (Niagen/ChromaDex) argues that direct NAD+ cannot enter cells intact because of its size and phosphate groups - it is degraded extracellularly to nicotinamide riboside (NR) or nicotinamide, which then re-enter cells and are reassembled into NAD+. David Sinclair (Harvard) and the NMN camp argue that direct NAD+ raises tissue levels regardless of the conversion pathway, and that the practical outcome (raised intracellular NAD+) is what matters. For the customer in front of you: direct injectable NAD+ works clinically - energy, cognition, recovery improvements are well-reported in both IV-clinic and community subQ data - but the bulk of human RCT evidence is on oral NR and NMN precursors. Injectable NAD+ has decades of IV-clinic use (substance-use protocols, anti-aging clinics) and emerging subQ trial data, but no large Phase 3 RCT.
Typical dose ranges by experience level - educational reference. Message us and we tailor it to you.
Almost every first-time NAD+ user underestimates how painful the subQ injection is. Starting at 25 mg lets you calibrate technique (inject slowly, deep subQ, rotate sites) before going higher. Mental clarity is usually the first thing people notice, within 3-7 days. NJ3100 kit (100 mg/vial) is the right starter size - 1 ml BAC water per vial, each vial gives 4 days at 25 mg or 2 days at 50 mg.
This is where most PP customers settle long-term. NJ500 kit covers ~25 weeks at 100 mg 2x/week (the standard maintenance protocol). NJ1000 kit is best value per mg and what most experienced users buy once they know they tolerate it. Split-dose users typically do morning 50 mg + early afternoon 50 mg to avoid sleep disruption from the evening pinch.
Advanced users frequently pair with IV NAD+ at a clinic for a "loading" phase (500-1000 mg IV 2-3x per week for 2-4 weeks) followed by subQ maintenance. PP doesn't ship the IV protocol but customers commonly do this combo. Above 300 mg per single subQ session almost no one tolerates the pain; the ceiling is technique-limited, not safety-limited.
Straight talk - what people actually report, and what the studies measured.
Peer-reviewed studies and clinical guidelines - tap any to read the source.
](https://pmc.ncbi.nlm.nih.gov/articles/PMC11365583/) - NMN human RCT meta-analysis, safety up to 1200 mg/day
Read study ↗PubMedSafety evaluation of beta-NMN oral administration in healthy adults (PMC9400576)](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400576/) - NMN safety profile, 12-week dosing
Read study ↗PubMedChronic NR supplementation elevates NAD+ in middle-aged and older adults (PMC5876407)](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876407/) - Martens et al, foundational NR pharmacokinetics paper
Read study ↗PubMedNR in older adults with mild cognitive impairment, RCT (PMC10828186)](https://pmc.ncbi.nlm.nih.gov/articles/PMC10828186/) - placebo-controlled cognitive endpoint trial
Read study ↗PubMedIV NAD+ vs NR tolerability pilot study (PMC12907335)](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12907335/) - direct comparison of injectable vs precursor tolerability in clinic setting
Read study ↗PubMedComplex NADASE Infusions in Substance Use Disorder, 50 cases (PMC11823434)](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11823434/) - clinical case series on high-dose IV NAD+ protocols
Read study ↗Aggregated sentiment from public forums & socials - real-world reports, not individual endorsements.
Injection-site pain: universal and severe enough to be the #1 NAD+ complaint on r/Peptides and TikTok. Users describe it as a "burning/stinging" that lasts 30-90 seconds during injection, sharper if pushed fast. This is THE thing that makes new NAD+ customers either commit or drop the protocol within the first week.
- Divergence: Clinical trials report this as a tolerable AE; community reports rate it as worse than any other common peptide. Real-world dropout rate due to pain is meaningfully higher than the trial AE data suggests.
Mental clarity / "lifting brain fog": the most commonly cited positive effect in community, usually within first 3-7 days at therapeutic dose
Sustained energy (not stimulant-like, more "wake up rested"): reported by majority of long-term users
Sleep disruption if injected late in the day: common; standard advice is morning-only dosing
Mild flushing / chest tightness in first 30 seconds: matches the trial signal; users describe it as "the rush" and learn to expect it
Route: SubQ (preferred for PP customers - small daily doses, no needing IV access); IM and IV are alternatives, IV requires a clinic
Injection site: abdomen, outer thigh, or upper glute. Rotate sites; NAD+ is notoriously painful at the injection site so site rotation matters more than for most peptides.
Storage: refrigerated, ~28-30 days. Powder is stable at room temp before recon but refrigerate for best longevity. Light-sensitive; keep in the box.
Notes: Inject VERY slowly. NAD+ subQ produces a stinging/burning sensation at the site that lasts 30-90 seconds, and pushing the plunger fast turns it into a sharp local pain that can last several minutes. Many users pre-mix with a small volume of lidocaine-containing BAC water (clinics do this), but standard BAC water works fine if you go slow. Some users also report a brief flushing / chest tightness / mild "rush" sensation in the first 30 seconds of injection, especially at higher single doses - this is benign and is the same flushing signal seen with niacin (NAD+ shares part of the same metabolic family). Splitting a larger dose into 2 smaller injections at different sites reduces both the local pain and the systemic flush.