Nootropic · 10mg × 10 vials
In plain terms: Pinealon is a research compound - injectable, fast-acting and well studied.
Pinealon is the Khavinson pineal-CNS bioregulator: a short synthetic tripeptide with the sequence Glu-Asp-Arg (EDR), designed at the St. Petersburg Institute of Bioregulation and Gerontology as a defined-synthetic successor to the original Epithalamin pineal extract. Where Epithalon (Ala-Glu-Asp-Gly, the AEDG tetrapeptide) is the pineal bioregulator pulled toward the telomerase/circadian axis, Pinealon was developed as the pineal/CNS-targeted member of the same family, designed to cross the blood-brain barrier readily and act inside neurons. Mechanistically Pinealon enters cells, translocates to the nucleus, and binds directly to gene promoter regions to modulate transcription. Khavinson's group has shown it upregulates expression of neuronal survival and antioxidant genes (SOD, glutathione peroxidase, Bcl-2 family), reduces apoptosis in cortical and cerebellar neurons under oxidative or hypoxic stress, normalizes calcium signaling in aged neurons, and increases serotonin and norepinephrine turnover in rodent brain regions tied to mood and cognition. In animal models of cognitive decline, hypoxia, prenatal stress, and Alzheimer's-like beta-amyloid challenge, Pinealon improves spatial memory and working memory and reduces neuronal cell death. Plain customer framing: Pinealon is the "CNS arm" of the Khavinson longevity series, a short pineal-derived tripeptide that gets into the brain easily and pulses neuronal gene expression back toward a younger, more stress-resilient pattern. The signal during a 10-day pulse is often a felt cognitive/mood lift (clearer thinking, steadier baseline, better sleep), and the underlying mechanism is gene-expression and neuronal-resilience reset rather than acute receptor agonism.
Typical dose ranges by experience level - educational reference. Message us and we tailor it to you.
10 mg/day is the dose used in most published Russian Pinealon work and the community standard starting point. Unlike Thymalin (where 5 mg is the cautious entry), Pinealon's safety profile is clean enough that 10 mg from day 1 is the standard first-pulse approach. One PIN10 kit (10 vials × 10 mg = 100 mg total) covers exactly one 10-day pulse at 10 mg/day. Subjective signal during the pulse: many users report a noticeable cognitive lift (clearer thinking, sharper focus, steadier mood) within the first 3-5 days, which makes Pinealon one of the more "felt" Khavinson peptides during the pulse window.
20 mg/day for 10 days is the upper end of the Russian protocol range and the dose most experienced Khavinson-stack customers land on after their first beginner pulse. One PIN20 kit (10 vials × 20 mg = 200 mg total) covers exactly one 10-day pulse at 20 mg/day. Split AM/PM dosing (10 mg morning, 10 mg early afternoon, last dose by 3-4 pm to avoid sleep disturbance in stim-sensitive users) is the community-preferred administration at this dose. The cognitive signal is stronger and more consistent at 20 mg than 10 mg in most user reports.
20-day protocols come from the older Russian Khavinson cohorts and are the standard advanced extension when paired with concurrent Epithalon and Thymalin pulses for the full longevity stack. The 30 mg/day compression protocol is community-driven rather than from published Khavinson originals; used mainly by customers running short pre-event cognitive enhancement (exam prep, high-output work sprints) where they want the full pulse compressed into 10 days. Advanced users almost universally pair Pinealon with concurrent Epithalon (sometimes also Thymalin) during the same 10-20 day window, since the published Khavinson protocol always combines multiple bioregulators rather than running any single one in isolation.
Straight talk - what people actually report, and what the studies measured.
Peer-reviewed studies and clinical guidelines - tap any to read the source.
mechanistic paper on how short Khavinson peptides including Pinealon penetrate cells and bind directly to DNA promoter regions to modulate transcription
Read study ↗PubMedKhavinson VK, Anisimov VN - Peptide bioregulation of aging: results and prospects, Biogerontology 2010comprehensive review of the Khavinson peptide bioregulator program including Pinealon, Epithalon, and Thymalin within the same tissue-specific peptide framework
Read study ↗PubMedArutjunyan A, Kozina L, Stvolinskiy S, Bulygina Y, Mashkina A, Khavinson V - Pinealon protects the rat offspring from prenatal hyperhomocysteinemia, Int J Clin Exp Med 2012neuroprotection in a prenatal stress model, reduces neuronal apoptosis and improves offspring cognitive outcomes
Read study ↗PubMedKhavinson VK, Lin'kova NS, Kvetnoy IM et al - Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture, Bull Exp Biol Med 2012Pinealon's effect on melatonin synthesis machinery in cultured pinealocytes, supporting the pineal-axis framing
Read study ↗PubMedMendzheritskii AM, Karantysh GV, Ryzhak GA, Prokof'ev VN - Effect of Pinealon on parameters of oxidative stress and cyclooxygenase-2 in serum of rats during aging, Adv Gerontol 2014antioxidant gene-expression and oxidative stress reduction in aged rats
Read study ↗PubMedKhavinson VK, Lin'kova NS et al - Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins, Bull Exp Biol Med 2014broader transcriptomic effects of the short Khavinson peptides including Pinealon
Read study ↗Aggregated sentiment from public forums & socials - real-world reports, not individual endorsements.
Felt cognitive lift during the pulse: the most consistent community signal. Users describe clearer thinking, sharper focus, easier word retrieval, and a steadier mood baseline, often noticed by day 3-5 of the pulse. Unlike Thymalin (where most users feel nothing during the course) and unlike Epithalon (where the signal is sleep/dreams), Pinealon is one of…
Improved sleep quality: secondary signal, less universal than the cognitive lift. Some users report deeper sleep and easier morning wake during the pulse, attributed to the pineal/melatonin pathway influence.
Mild stimulation / late-day alertness: a subset of users report feeling slightly wired if dosing late in the day, which is the reason morning or early-afternoon administration is the community default. Resolves by shifting the dose earlier.
Mood lift / reduced low-grade depression: reported by a meaningful subset of users, attributed to the serotonin/norepinephrine turnover effects shown in rodent studies
Headache: occasional, usually mild and self-limiting in the first 1-3 days of a pulse, less common than with Epithalon
Vivid dreams: occasionally reported when stacked with concurrent Epithalon, more likely attributable to the Epithalon side of the stack
Route: SubQ injection is the PP default and the community-standard outpatient route. IM is documented in the original Khavinson Russian protocols. Intranasal use is reported in some Russian clinical studies (Pinealon's small size and BBB penetration make IN delivery plausible) but SubQ is what the catalog/community defaults to.
Injection site: abdomen, outer thigh, or upper outer arm; rotate sites across the 10-day pulse since you are hitting the same site daily.
Storage: refrigerated, ~28 days after reconstitution. The 10-day pulse window sits well inside that shelf, so storage is not a practical constraint. Lyophilized vials store room temp short-term, refrigerate or freeze for longer hold.
Notes: Morning or early-afternoon dosing is the most common community choice when running Pinealon for cognitive lift, since evening dosing can produce a mild stimulating signal in a subset of users. When Pinealon is being run for the sleep/pineal angle (less common, since Epithalon is the better tool for that), evening dosing pairs naturally. Don't shake the vial, swirl gently to dissolve. The peptide is small and stable but standard practice is amber-glass or fridge storage out of direct light.