Tissue Repair · 5mg × 10 vials
Thymosin beta-4 fragment. Actin-sequestering peptide studied for cell migration, angiogenesis and tissue repair; often paired with BPC-157.
TB-500 is the N-acetyl active fragment of thymosin beta-4, a naturally occurring 43-amino-acid peptide present in nearly every cell and found at especially high concentrations in wound fluid and platelets. Its primary mechanism is actin sequestration: thymosin beta-4 binds G-actin monomers and regulates assembly of the actin cytoskeleton, the process that allows cells to migrate to sites of injury, form new tissue, and build new blood vessels.
Downstream of that, three effects dominate the repair literature. It upregulates VEGF and other angiogenic factors, promoting capillary growth into damaged tissue. It activates progenitor and endothelial cells, driving migration and proliferation into the wound bed. And it dampens pro-inflammatory cytokines such as TNF-alpha and NF-kB signalling, reducing collateral inflammation. In animal models, thymosin beta-4 accelerates wound closure, increases collagen deposition, and in cardiac infarct models recruits epicardial progenitor cells into damaged myocardium. Full-length thymosin beta-4 has completed Phase 2 trials in dry eye, epidermolysis bullosa, and cardiac repair. TB-500 acts systemically on actin-driven cell migration, whereas BPC-157 acts mostly locally through VEGFR2 and growth-factor receptor expression, which is why the two are frequently studied in combination.
What the published studies measured.
Peer-reviewed studies and clinical guidelines - tap any to read the source.
](https://pubmed.ncbi.nlm.nih.gov/16183326/) - foundational mechanism review by the field's lead researchers
Read study ↗PubMedCrockford D et al - Thymosin beta-4: structure, function, and biological properties supporting current and future clinical applications, Ann NY Acad Sci 2010comprehensive properties review including wound healing, cardiac repair, neuroprotection
Read study ↗PubMedBock-Marquette I et al - Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair, Nature 2004the seminal cardiac repair paper that launched RegeneRx Phase 2
Read study ↗PubMedSmart N et al - Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization, Nature 2007progenitor cell mobilization mechanism
Read study ↗PubMedSosne G et al - Thymosin beta-4 promotes corneal wound healing and decreases inflammation in vivo, Exp Eye Res 2001dry eye / corneal indication
Read study ↗PubMedRuff D et al - Safety, pharmacokinetics, and pharmacodynamics of recombinant human Thymosin beta-4 in healthy volunteers, Ann NY Acad Sci 2010Phase 1 human PK/safety
Read study ↗Storage: refrigerated, ~28 days after reconstitution. Lyophilized vials keep refrigerated long-term, room temp acceptable for shipping windows.