Healing · 10mg × 10 vials
BPC tells the body to grow new blood supply into broken tissue, TB-500 tells the cells to move in, lay down structure, and quiet the inflammation.
Wolverine Blend is a pre-mixed single-vial combination of BPC-157 and TB-500 in a 1:1 ratio by mass. It exists because the two peptides are the canonical healing stack and they work on completely separate, non-overlapping mechanisms - combining them in one vial removes a reconstitution step and a separate draw without changing the pharmacology. BPC-157 (Body Protection Compound, a 15-amino-acid pentadecapeptide derived from a protective sequence in human gastric juice) works mostly locally: it upregulates VEGFR2 and drives new capillary formation into damaged tissue, modulates the nitric oxide system to protect against ischemia/reperfusion damage, and upregulates growth hormone receptor expression on fibroblasts (which is the proposed handoff to the GH axis for tendon healing). TB-500 (the N-acetyl active fragment of Thymosin Beta-4) works systemically: it binds G-actin monomers and regulates actin cytoskeleton assembly, which is what lets cells migrate to injury sites, build new tissue, and form new blood vessels. Downstream of that, TB-500 upregulates VEGF and other angiogenic factors, activates progenitor and endothelial cells into the wound bed, and dampens pro-inflammatory cytokines (TNF-alpha, NF-kB).
The two layer cleanly. BPC drives the local capillary growth and tells the tissue near the injection site to repair; TB-500 drives the systemic cell-migration and inflammation-resolution layer that BPC alone doesn't fully cover. In plain language: BPC tells the body to grow new blood supply into broken tissue, TB-500 tells the cells to move in, lay down structure, and quiet the inflammation. Together they cover the full repair cycle (angiogenesis, cell migration, tissue remodeling, inflammation resolution), which is why this stack became the default community answer for injury and recovery research over the last decade.
Typical dose ranges by experience level - educational reference. Message us and we tailor it to you.
This is the entry-level protocol for general recovery, training maintenance, minor soft-tissue niggles, or post-workout joint protection. BB10 reconstituted with 2 ml BAC = 5 mg/ml total blend = 2.5 mg/ml BPC + 2.5 mg/ml TB-500. So 0.1 ml = 10 IU delivers 250 mcg of each. One BB10 vial lasts 20 days at this dose; a 10-vial BB10 kit covers ~200 days of continuous use, well past a full 8-12 week cycle. Effect is gradual - don't expect overnight, expect noticeable improvement 2-4 weeks in.
Standard working dose for an actual soft-tissue injury (tendinitis, ligament strain, muscle tear, post-surgical recovery), chronic overuse research, or rotator cuff/Achilles/plantar fasciitis protocols. BB10 reconstituted with 2 ml BAC at 0.2 ml = 20 IU delivers 500 mcg of each. Or use BB20 (10 mg/ml of each) and dose 0.1 ml = 10 IU for the same 500 mcg + 500 mcg. The BB20 is more efficient at this dose band - one vial lasts 20 days at 500 mcg daily and the kit covers ~200 days. Split AM/PM dosing is preferred for acute injury because of BPC's short ~4 hr plasma half-life - keeps the angiogenic signal steadier through the day.
At this band the blend's fixed 1:1 ratio becomes a real constraint - TB-500 loading wants 2.5 mg twice weekly while BPC wants 250-500 mcg daily, a 10× difference. Drawing 2.5 mg TB-500 from BB10 means 1 ml = 100 IU per dose (impractical) AND would deliver 2.5 mg BPC at the same time (excessive). Two clean ways through this: (1) run separate BC10 + BT10 vials and combine at draw time so you can dose them independently, which is what most advanced users do; or (2) use the BB20 for the loading-dose injections (10 mg/ml of each, 2.5 mg TB = 0.25 ml = 25 IU but you also deliver 2.5 mg BPC in that draw twice weekly which is fine as a periodic high dose) and run a separate BC vial for the daily BPC maintenance. Top-end protocols come from horse racing / equine recovery dosing where weight-adjusted doses are higher. Community advanced users rarely exceed 1 mg total BPC + 5-10 mg/wk TB-500 because returns flatten beyond that.
Straight talk - what people actually report, and what the studies measured.
Peer-reviewed studies and clinical guidelines - tap any to read the source.
foundational BPC mechanism + animal evidence
Read study ↗PubMedChang et al, J Appl Physiol 2011 - BPC 157 promotes tendon healing through VEGFR2defines the VEGFR2 angiogenic mechanism for the BPC component
Read study ↗PubMedHsieh et al, J Orthop Res 2017 - "BPC 157 promotes tendon healing"Achilles tendon transection model, tenocyte proliferation
Read study ↗PubMedGoldstein AL, Hannappel E, Kleinman HK - Thymosin beta-4: actin-sequestering protein moonlights to repair injured tissues, Trends Mol Med 2005foundational TB-4 mechanism review by the field's lead researchers
Read study ↗PubMedCrockford D et al - Thymosin beta-4: structure, function, and biological properties, Ann NY Acad Sci 2010TB-4 comprehensive properties review including wound healing, cardiac repair, neuroprotection
Read study ↗PubMedBock-Marquette I et al - Thymosin beta4 activates ILK and promotes cardiac cell migration, survival and cardiac repair, Nature 2004seminal TB-4 cardiac repair paper that launched RegeneRx Phase 2
Read study ↗Aggregated sentiment from public forums & socials - real-world reports, not individual endorsements.
First-week fatigue / lethargy: most-reported sensation with the blend, primarily attributed to the TB-500 component. r/Peptides and r/PeptideHQ users describe a "drag" or "groggy" feeling during the first 5-10 days. ~30-40% of users mention it on community threads.
Injection site irritation: mild redness or tenderness for a few hours post-injection, BPC component-driven. Resolves on its own. Rotating sites minimizes it.
Mild GI changes: a few users report transient loose stool or appetite shifts in the first week, especially at higher doses. Generally resolves by week 2.
"Old injury flare-up" sensation: some users describe transient achiness in previously-healed injury sites during loading, framed by community as "the body remembering and re-healing." Not documented, anecdotal.
Mild dizziness or lightheadedness: minority report, usually first injection or two. Settles.
Vivid dreams: occasionally reported, no formal mechanism, possibly linked to either BPC (which has community-reported sleep effects) or TB-500.
Route: SubQ (community default), local SubQ near injury site (chiropractor/sports-med-preferred), IM tolerated
Injection site: abdomen, outer thigh, or love handle for systemic effect. Local SubQ near the injury site (closest skin to the affected tendon/joint) is the community and chiropractor-favored route for targeted joint/tendon work. Rotate sites if injecting systemically.
Storage: Refrigerated, ~28 days after reconstitution. Lyophilized vials room-temp acceptable for shipping windows; refrigerate on arrival.
Notes: Solution should be clear after reconstitution; cloudiness means a bad recon or contamination, discard. Don't shake - swirl gently. The two peptides are physicochemically compatible in the same vial; this is also exactly what experienced users do when running BC10 + BT10 separately (combine in the same syringe at draw time). Some users dose pre-bed because BPC has community-reported sleep benefits, but TB-500's slow half-life means timing within the day doesn't matter much for the systemic effect.