NA-Selank Amidate (N-Acetyl Selank Amidate)

What Is NA-Selank Amidate (N-Acetyl Selank Amidate)?

NA-Selank Amidate is the chemically stabilised analogue of Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro), itself a synthetic analogue of tuftsin, the endogenous immunomodulatory tetrapeptide cleaved from IgG. Two modifications are applied to the parent heptapeptide. The N-terminus is acetylated, which blocks aminopeptidase cleavage and slows enzymatic breakdown in serum and mucosal tissue. The C-terminus is amidated, converting the free carboxylic acid to an amide, which blocks carboxypeptidase cleavage and modestly increases lipophilicity, theoretically aiding blood-brain-barrier penetration.

Capping both ends gives the molecule a meaningfully longer functional window than native Selank, which is otherwise degraded within minutes. The pharmacologically active core, and therefore the downstream mechanism, is unchanged: GABA-A receptor expression upregulation for the anxiolytic effect without binding the benzodiazepine site, a serotonergic arm that raises brain serotonin metabolism via 5-HIAA, hippocampal BDNF upregulation, and residual tuftsin-derived immunomodulatory activity on interferon and cytokine output. NA-Selank Amidate therefore does what Selank does at the receptor level for a longer period per exposure. The stabilised form has no independent clinical literature; its evidence base is inferred from the parent compound.