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RESEARCH
RESOURCES

Guides, calculators, stacking references, and curated academic literature for every compound we carry. Everything a researcher needs in one place.

Research Use Only Not for Human Consumption 18+ to Purchase
All content in this library is for educational and research purposes only. Compounds referenced are sold strictly for in-vitro research. Not for human or animal consumption. Purity Peptides does not provide medical advice.
/ Tools & Guides
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Beginner Guide
Peptide 101
What is a research peptide? How lyophilization works, why purity matters, and what COAs actually tell you. Start here if you're new.
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Preparation Guide
Reconstitution Guide
Step-by-step: how to reconstitute any lyophilized peptide with bacteriostatic water. Includes supplies list, storage rules, and FAQ.
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Interactive Tool
Dosing Calculator
Enter vial size and BAC water volume to get concentration, per-unit dose, and a full syringe reference table. Works for any peptide.
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Stacking Reference
Peptide Stacking Guide
Popular research stacks: GH optimization, body composition, recovery, and anti-aging. Rationale, compound roles, and timing references.
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/ Compound Reference
PRODUCT RESEARCH PAGES
Metabolic Research
Retatrutide (GLP-3)
GLP-1/GIP/glucagon triple agonist. Mechanism, clinical trial data, variants, reconstitution, and COA.
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 Metabolic Research
Tirzepatide (GLP-1/GIP)
Dual GIP/GLP-1 agonist. SURMOUNT trial data, receptor pharmacology, and research context.
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 Metabolic Research
Semaglutide (GLP-1)
GLP-1 receptor agonist. STEP-1 trial context, metabolic research, peptide structure.
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 Tissue Research
BPC-157
Gastric pentadecapeptide. Tissue repair, angiogenesis, and gut barrier research context.
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 Dermal Research
GHK-Cu
Copper tripeptide. Collagen synthesis, wound healing, and anti-aging research context.
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 GH Secretagogues
HGH (Somatropin)
Recombinant human growth hormone. Pituitary axis, IGF-1 axis, and research applications.
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 GH Secretagogues
Ipamorelin / CJC-1295
GHRP + GHRH combination stack. GH pulse amplitude and frequency research.
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 Mitochondrial Research
NAD+
Nicotinamide adenine dinucleotide. Mitochondrial function, sirtuin activation, and aging research.
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 Tissue Research
TB-500 (Thymosin Beta-4)
Actin-sequestering peptide. Tissue repair, inflammation modulation, and angiogenesis research.
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 Melanocortin Research
Melanotan II
Melanocortin receptor agonist. Melanogenesis, UV protection research, and MC-R pharmacology.
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 Endocrine Research
PT-141 (Bremelanotide)
Melanocortin agonist. CNS-mediated research applications and receptor pharmacology.
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 Neuropeptide Research
Semax
ACTH-derived nootropic peptide. BDNF upregulation and neuroprotection research context.
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/ Academic Literature
CURATED STUDIES
GLP-1 / Metabolic Research
Retatrutide Phase 2 Trial — Triple Agonist for Obesity
Jastreboff et al. · NEJM 2023 · GLP-1/GIP/Glucagon
Phase 2 dose-escalation trial of retatrutide (LY3437943) in adults with obesity. Mean body weight reduction of up to 24.2% at 48 weeks.
PubMed ↗
SURMOUNT-1 — Tirzepatide for Obesity (Phase 3)
Jastreboff et al. · NEJM 2022 · PMID 35658024
72-week randomized trial. Tirzepatide 15mg produced 20.9% mean body weight reduction vs. 3.1% for placebo. Established benchmark for GIP/GLP-1 dual agonism.
PubMed ↗
STEP-1 — Semaglutide 2.4mg for Weight Management
Wilding et al. · NEJM 2021 · PMID 33567185
68-week trial. Semaglutide produced 14.9% mean body weight reduction. First phase 3 GLP-1 data to demonstrate double-digit weight loss vs. placebo.
PubMed ↗
AOD-9604 — Anti-Obesity Effects of GH Fragment
Heffernan et al. · Am J Physiol Endocrinol Metab 2001
AOD-9604 (hGH fragment 176-191) stimulates lipolysis and inhibits lipogenesis in adipocytes without affecting insulin sensitivity or IGF-1 levels.
PubMed ↗
Tissue Research
BPC-157 — Stable Gastric Pentadecapeptide: Review
Sikiric et al. · Curr Pharm Des 2018 · PMID 30027844
Comprehensive review of BPC-157's proposed mechanisms: angiogenesis, growth factor modulation (VEGF, EGF), and gut-brain axis interactions across animal models.
PubMed ↗
Thymosin Beta-4 (TB-500) in Tissue Repair and Angiogenesis
Goldstein & Kleinman · Ann NY Acad Sci 2015 · PMID 25773628
Review of thymosin beta-4's role in wound healing, actin polymerization regulation, and promotion of neovascularization. Active area of wound care research.
PubMed ↗
KPV Tripeptide — Anti-Inflammatory Mechanisms
Dalmasso et al. · J Crohns Colitis 2008
Alpha-MSH-derived tripeptide KPV demonstrates anti-inflammatory properties in intestinal epithelial cells via NF-kB pathway inhibition in preclinical models.
PubMed ↗
Dermal Research
GHK-Cu — Human Skin Remodeling via Copper Peptide
Pickart & Margolina · Biomolecules 2018 · PMID 30022165
GHK-Cu stimulates collagen and glycosaminoglycan synthesis, activates antioxidant enzymes, and modulates over 4,000 human genes including those controlling skin repair.
PubMed ↗
Epithalon — Telomere Elongation and Aging
Khavinson et al. · Bull Exp Biol Med 2003 · PMID 14631430
Tetrapeptide Epithalon (Epitalon) demonstrated telomerase activation in human somatic cells in vitro, increasing telomere length and extending cellular lifespan in preclinical models.
PubMed ↗
Melanotan II — Melanocortin Receptor Pharmacology
Wikberg · Pharmacol Res 1999 · PMID 10588310
Review of melanocortin receptor subtypes (MC1R-MC5R), ligand selectivity, and research applications. Foundational pharmacology reference for Melanotan analogs.
PubMed ↗
GH Secretagogues
Ipamorelin — Selective GH Secretagogue Without Cortisol Effect
Raun et al. · Eur J Endocrinol 1998 · PMID 9820010
Ipamorelin selectively stimulates GH release with minimal effect on prolactin, ACTH, or cortisol — distinguishing it from earlier GHRPs. Foundational selectivity study.
PubMed ↗
CJC-1295 — Sustained GH and IGF-1 Elevation
Teichman et al. · J Clin Endocrinol Metab 2006 · PMID 16352683
CJC-1295 (with DAC) produced dose-dependent increases in GH and IGF-1 levels lasting up to 6 days in healthy adults. First CJC-1295 human pharmacokinetic data.
PubMed ↗
Tesamorelin — Visceral Adiposity Reduction in Clinical Trial
Falutz et al. · NEJM 2010 · PMID 20427812
Randomized trial of tesamorelin (GHRH analog) demonstrating significant reduction in visceral adipose tissue. FDA-approved application as reference for GHRH analog research.
PubMed ↗
Mitochondrial & Neuropeptide Research
MOTS-C — Mitochondrial-Derived Peptide Regulating Metabolism
Lee et al. · Cell Metab 2015 · PMID 25738459
Discovery paper for MOTS-C. Mitochondrial-encoded peptide that regulates nuclear gene expression, enhances insulin sensitivity, and promotes metabolic homeostasis in mice.
PubMed ↗
NAD+ Metabolism and Its Role in Aging
Yoshino et al. · Cell Metab 2018 · PMID 30243858
Oral NMN supplementation restored NAD+ levels and improved muscle insulin sensitivity in postmenopausal women with prediabetes. Key NAD+ metabolism human trial.
PubMed ↗
Semax — BDNF Upregulation and Neuroprotection
Dolotov et al. · J Neurochem 2006 · PMID 16643424
ACTH-derived heptapeptide Semax increases BDNF and NGF expression in rat brain. Mechanism study for Semax's observed neuroprotective and nootropic effects in preclinical models.
PubMed ↗
Selank — Anxiolytic and Nootropic Effects
Zozulya et al. · CNS Drug Rev 2001 · PMID 11455789
Tuftsin analog Selank demonstrated anxiolytic activity and memory enhancement in animal models. Review covers receptor interaction and GABAergic modulation mechanisms.
PubMed ↗
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