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RESEARCH

ARA-290

Cibinetide · EPO-Derived 11-mer Tissue Protective Peptide

Erythropoietin-derived 11-mer peptide. Studied in nerve protection, neuropathic pain, and inflammatory pathway research without erythropoietic effects.

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Research Data

What Is ARA-290?

ARA-290 (Cibinetide) is an 11-amino acid peptide derived from the EPO helix B surface region. It activates the innate repair receptor (IRR) — a heterodimer of EPO receptor and CD131 — that mediates EPO's tissue-protective effects without erythropoietic activity. Research focuses on neuropathic pain, inflammation, and diabetic neuropathy models.

Research Context

  • Innate repair receptor (IRR) activation without erythropoiesis
  • Neuropathic pain pathway research — small fiber neuropathy models
  • Anti-inflammatory effects via IRR-mediated macrophage modulation
  • Diabetic neuropathy pathway research — Phase 2 clinical data
  • Beta cell protection research in type 1 diabetes models

Storage & Reconstitution

Store lyophilized at -20°C. Reconstitute in sterile saline. Stable 4 weeks at 2–8°C.

All products sold for research purposes only. Not for human or animal consumption. Must be 21 or older to purchase. By placing an order you confirm compliance with all applicable local laws and regulations.