FOXO4-D-Retro-Inverso Peptide · Senolytic
D-retro-inverso FOXO4 peptide. Studied as a senolytic — selectively inducing apoptosis in senescent cells while sparing healthy cells.
FOXO4-DRI is a D-retro-inverso peptide based on the FOXO4 interaction domain with p53. Senescent cells maintain survival by nuclear FOXO4-p53 interaction. FOXO4-DRI disrupts this interaction, releasing p53 to trigger apoptosis selectively in senescent cells. Research in mouse models has shown restoration of physical fitness and fur density, and improved renal function after clearing senescent cells.
Store lyophilized at -20°C. Reconstitute in sterile water. Stable 4 weeks at 2–8°C. Expensive — handle with care.