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AICAR

5-Aminoimidazole-4-Carboxamide Ribonucleotide · AMPK Activator

AMPK activator and exercise mimetic. Studied in mitochondrial biogenesis, endurance capacity, glucose metabolism, and metabolic research.

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Research Data

What Is AICAR?

AICAR (acadesine) is a cell-permeable AMP analog that activates AMPK by mimicking an increased AMP:ATP ratio. Research documents activation of PGC-1α and GLUT4 expression, mitochondrial biogenesis, fatty acid oxidation, and improved endurance in animal models. A foundational compound in exercise mimetic and metabolic research.

Research Context

  • AMPK activation mechanism and downstream pathway mapping
  • PGC-1α and mitochondrial biogenesis research
  • Endurance capacity — AICAR vs trained vs sedentary animal models
  • GLUT4 upregulation and glucose uptake pathway research
  • Synergy with GW501516 in exercise mimetic research protocols

Storage & Reconstitution

Store lyophilized at -20°C. Reconstitute in sterile saline or PBS. Stable 4 weeks refrigerated.

All products sold for research purposes only. Not for human or animal consumption. Must be 18+ to purchase. By placing an order you confirm compliance with all applicable local laws and regulations.