Afamelanotide · Linear Alpha-MSH Analog
MC1R-selective alpha-MSH analog. Studied in melanogenesis pathway models.
Melanotan I (afamelanotide) is a synthetic linear analog of alpha-melanocyte stimulating hormone (alpha-MSH). It activates MC1R receptors on melanocytes to stimulate eumelanin production, increasing skin pigmentation independent of UV radiation. It received EU approval (as Scenesse) for erythropoietic protoporphyria, providing clinical validation for MC1R-driven photoprotection.
Store lyophilized at -20°C. Reconstituted: 2–8°C, use within 4–6 weeks.